Endocrine Abstracts

Introduction: The reccurence rate after successful neurosurgery for patients with Cushing’s disease (CD) varies between 10% and 65%. It is shown earlier that some features are associated with the probability of recurrence, yet no rules were elaborated how to analyse the set of variables.Materials and methods: The retrospective study was based on 219 cases of CD (32 men, 187 women) with a disease duration ranged from 4 months to 22 years, who underwe...

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder resulting from oversecretion of parathyroid hormone (PTH) in parathyroid glands. Hypocalcemia can occur in the postoperative period after parathyroidectomy (PTE) and can be challenging to control and requires varying doses of supplementation. Vitamin D deficiency can worsen the severity of PHPT and promote the development of “hungry bone syndrome” due to increased influx of calcium into bon...

Objective: The search for the predictors of the Cushing’s disease (CD) recurrence after surgical treatment among the following parameters - gender, age, adenoma size, preoperative levels of ACTH (morning) and cortisol (evening) in the blood, postoperative levels of ACTH (morning) and cortisol (morning) in the blood.Material and methods: A retro- and prospective monocenter study of treatment outcomes in 181 patients with confirmed diagnosis of Cushin...

Background: In some patients with primary hyperparathyroidism (PHPT), glomerular filtration rate (GFR) demonstrate decrease after parathyroidectomy (PTE). GFR may decrease immediately after surgery due to general anesthesia, but after a month not all patients restore kidney function; a decreased GFR is also observed after 1–2 years after surgery.Aim: To find the pre-surgical factors of GFR decrease after PTE.Methods: Patients ...

Introduction: Insulinoma visualization is the most difficult stage of diagnosis of this disease. Currently, in most cases the contrast-enhanced multislice computer tomography of abdomen and retroperitoneal space (CE-MSCT) is the method of choice in topical diagnosis of insulinoma. This method is associated with radiation exposure and administration of contrast agents, so it is invasive. Thus, an alternative highly informative and safe method for initial topical diagnosis of in...

Objectives: To assess the frequencies of hyponatremia and central diabetes insipidus (CDI) after transnasal adenomectomy and to identify its risk factors.Patients and methods: The study included 152 patients aged 18 to 65 years (median [Q1; Q3] 40 [31; 52]) who underwent endoscopic endonasal transsphenoidal surgery due to Cushing’s disease, acromegaly, prolactinoma, non-functioning pituitary adenoma, thyreotropinoma or Nelson’s syndrome at Endo...

The course and predictors of postoperative diabetes insipidus.Objectives: To evaluate the course and predictors of permanent and transient postoperative diabetes insipidus (DI).Patients and Methods: The study included 152 patients undergoing endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40. 73 patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inacti...